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Tainted Magdalene synergizes with Tainted Bethany as due to Tainted Maggy's generation of heart pickups, Tainted Bethany can quickly accumulate Blood Charges.Similarly, effects that trigger on damage, such as It Hurts trigger on players who take damage, regardless of who took damage.On kill effects such as Infestation 2, Lusty Blood, or Tainted Keeper's coin drops will trigger for the player holding it regardless of which player killed the enemy.Keeper/ Tainted Keeper will not replace heart drops with flies when paired with other characters that use hearts.Tainted Cain can also work, since his Bag of Crafting entirely bypasses the reroll mechanic. Since there will be significantly less health-up sources as a result, it's recommended to pair Tainted Lost with characters who can't use red health, like ?, Keeper, Tainted Judas, Tainted ?, Tainted Keeper, Tainted Forgotten, or Tainted Bethany.Tainted Lost's reroll mechanic will apply in co-op, but this still includes the reroll of any items not labelled as 'offensive'.

Lucky Foot will not convert pills unless Cain holds them, so it can still be a negative pill if used by Lazarus.Cain can pair well with Lazarus, as Cain can take Lazarus' pill to have it be a guaranteed positive or neutral pill for Cain.It's best to pair Magdalene up with characters who benefit or rely heavily on red health, such as Samson, The Forgotten, or Bethany. Magdalene not only heals herself with Yum Heart, but also heals all other co-op players for a Half Red Heart.On the Nintendo Switch, you must restart the game after setting up the controllers or the join button will not work.Because at least 1.5 hearts are required for co-op, Player 2 cannot join when playing as The Lost.This limit increases by one Red Heart container, Soul Heart, or Black Heart when using Red Baby, Blue Baby, or Black Baby, respectively.The maximum amount of hearts Player 2 can have is three Red Hearts and one Soul Heart, using Scapular.If Isaac has a maximum of 12 hearts, including Soul Hearts and Black Hearts, Player 2 will take three hearts instead of one or two.If Isaac has more than 6 total hearts, including Soul Hearts and Black Hearts, Player 2 will take two hearts instead of one.The last shooting familiar Isaac picked up will follow Player 2 instead of Isaac.However, some special babies have detrimental effects. The appearance of a majority of the co-op babies is solely cosmetic, but there are several 'special' babies with beneficial effects.If player 2 dies, they can rejoin the game at the cost of another Red Heart container, as a new random Baby.

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Soul Hearts will be given to Player 2 before normal hearts, and half hearts will be given before full hearts.All damage players do to bosses is reduced by 20%, including the damage from items, familiars, or bombs. All players share resources (coins, bombs, and keys), but each have their own hearts and items. When a boss is killed, the item pedestal will spawn as many items as there are players. Once the boss of a floor is killed, the dead player is reborn with all the items they once had, but with half a heart. If a player dies without any revival items, they become a ghost baby that can only deal minimal damage and press buttons. If you start a normal game and player 2/3/4 presses Start while in the starting room, a mini character selection wheel displays at the top of the screen, with which that player can choose any unlocked character, or a random character. Dying as one of the available special babies will remove it from the pool.

Joining as a co-op baby will bring up a menu that allows the player to pick from 5 special babies. Babies always have flight, but they cannot interact with objects like items and pickups, except for certain special babies like Magnet Baby and Isaac 2. Subsequent pressing of the join button will despawn the baby, giving Isaac the Red Heart container back.īabies share Isaac's stats except for health and damage babies deal half of Isaac's damage. (These versions can also support up to 4 players.)Ĭo-op players can join in at any time as a random baby, taking a Red Heart container away from Isaac and giving it to the second player. The PlayStation 4 and Steam versions of the game are capable of both local and online multiplayer via PS4's 'Share Play' and Steam's 'Remote Play Together' features, as well as a dedicated online multiplayer system in early beta. The Afterbirth DLC increased this to 4 player local co-op. Rebirth features 2 player local co-op on PC. For items that follow Isaac, see familiar.